Elsewhere on the opening weekend, Manchester United host Leicester City, Liverpool entertain West Ham, and Championship winners Wolverhampton Wanderers welcome Everton to Molineux.
Promoted Fulham host Crystal Palace, while Cardiff visit Bournemouth.
Tottenham begin the season with a trip to Newcastle’s St James’ Park – one of three away games in their opening four league matches.
It is unclear if Spurs’ new £850m stadium will be available in time for the start of the new campaign, and they must confirm by Friday if they need to use Wembley for any home fixtures.
The three other fixtures on the opening weekend see Chelsea travel to Huddersfield, Southampton host Burnley, and Watford take on Brighton at Vicarage Road.
The Premier League has released dates for all 380 matches, but none have been allotted kick-off times as broadcasters are yet to decide which games will be televised.
The Champions League group stage will commence on 18-19 September, and last season’s beaten finalists Liverpool face an away Premier League fixture before all of their six group games. That includes trips to Arsenal, Chelsea and Tottenham.
Manchester United and Spurs are away four times before group games, while Manchester City are on the road twice before European fixtures.
Opening day 2018-19 Premier League fixtures:
Arsenal vs. Man City
Bournemouth vs. Cardiff
Fulham vs. Crystal Palace
Huddersfield vs. Chelsea
Liverpool vs. West Ham
Man Utd vs. Leicester
Newcastle vs. Spurs
Southampton vs. Burnley
Watford vs. Brighton
Wolves vs. Everton
More to follow.